C9275

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C9275

Sigma

 

Calcium Ionophore A23187 hemicalcium salt

powder

Synonym:A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt
CAS Number:59450-89-4
Linear Formula:C29H36Ca0.5N3O6
Molecular Weight:542.65
Beilstein Registry Number:6765084
MDL number:MFCD00077678
PubChem Substance ID:24893145

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Description

ApplicationIonophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Properties

formpowder
color yellow
solubilityDMSO: soluble
 ethanol: soluble
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36
WGK Germany3

References

referencePressman, B.C., et al., Biological applications of ionophores. Annu. Rev. Biochem. 45, 50-530, (1976)
 Kauffman, R.F., et al., Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J. Biol. Chem. 255, 2735-2739, (1980)
 Markram, H., and Segal, M., Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-D-aspartate. Brain Res. 540, 322-324, (1991)
 Knowles, R.G., and Moncada, S., Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17, 399-402, (1992)